Endothelial dysfunction or damage is characterized by reduction of the bioavailability of nitric oxide, which upsets the balance between vasoconstriction and vasodilation and initiates a number of processes that promote hypertension. In addition, endothelial damage includes increased endothelial permeability, platelet aggregation, proinflammatory and procoagulatory states, and monocytes migration from the blood into the subendothelial intima and transformation into macrophages, which accumulate lipids to form the lipid core of atherosclerotic plaque.
A technology that is fairly quick and simple to use involves fingertip infrared light transmission photoplethysmography, which performs digital pulse volume waveform Analysis and generates an automated reflection index (RI). Our device goes further that this and applies a patented spectral analysis of the wave harmonics, these measurements identify abnormal cardiovascular function, endothelial and blood flow dysfunction. Studies show that these methods could be easily integrated in daily practice and be very useful for the early detection of asymptomatic patients at high risk of arterial disease, autonomic neuropathy, and for CAD treatment follow-ups.
Cardiovascular Diseases
Endothelial dysfunction
Peripheral Artery Diseases (PAD)
Ankle Brachial Index is a non-invasive, quick test that has been shown to be a specific and sensitive metric for the diagnosis of Peripheral Arterial Disease (PAD). Additionally, the ABI has been shown to predict mortality and adverse cardiovascular events independent of traditional CV risk factors.
The ankle-brachial index test is recommended by AHA as part of a series of three tests, including the carotid ultrasound and abdominal ultrasound, to check for blocked or diseased arteries.
A low ankle-brachial index number can indicate narrowing or blockage of the legs arteries which increasing the risk of circulatory problems causing heart disease or stroke. A high ankle-brachial index number can indicate calcification of the legs arteries which increasing of mortality.
Silent Ischemia and cardiac sudden death
Sudden cardiac death is the most likely consequence of both men (50%) and women (64%) with coronary artery disease (CAD). Currently, the only available strategy to reduce mortality in the at-risk population is primary prevention. CAD is a multifactorial disease that usually develops many years before any clinical symptoms are manifest; it is caused by risk factors such as hyperlipoproteinemia, high cholesterol diet, smoking, and diabetes mellitus. Over the last dozen years, appreciation of the role of endothelial dysfunction in CAD has burgeoned, as well of cardiac autonomic neuropathy (CAN) in silent myocardial ischemia and cardiovascular morbidity.
Our Telemetry Cardiac monitor are the most advanced ambulatory monitoring in the market and automatically detects and transmits ECG data to a diagnostic laboratory in real-time. Light, easy to wear, these monitors allow detection of arrythmia in patient with history of stroke, angina, syncope, hypertension, cardiac autonomic neuropathy and more. Atrial fibrillation is the most common arrythmia and may represent a target for early clinical intervention to prevent heart failure re-hospitalization and reduce sudden cardiac death on patient at risk.
